Studies in Pittsburgh


Progesterone for the Treatment of TBI (PROTECT III) (COMPLETED)

Progesterone for the Treatment of Traumatic Brain Injury (ProTECTâ„¢ III) is a research study to see if progesterone, a hormone normally found in our bodies, is useful in limiting the amount of brain damage from traumatic brain injury (TBI).  ...


Prehospital Lactate (COMPLETED)

This observational study tests whether blood lactate levels in injured patients in an ambulance predicts the need for emergency surgery, blood transfusions or other complications. Lactate will be measured in a drop of blood from patients who...


Hypertonic Saline for Traumatic Brain Injury

This study examined whether patients who were unconscious after a traumatic head injury would have better outcomes when a concentrated salt solution (hypertonic saline) was used by paramedics as the initial intravenous fluid by paramedics.  ...


ROC – Hypertonic Resuscitation

This study examined whether patients with low blood pressure after severe injury would have better outcome when a concentrated salt solution was used by paramedics as the initial intravenous fluid. Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD...


ROC - Effect of Real-Time Feedback During CPR Outside Hospital

This randomized clinical trial examined whether a device that measured and provided feedback on CPR to paramedics would improve delivery of CPR and result in better patient survival after cardiac arrest. Cardiopulmonary resuscitation (CPR) consists...


ROC-PRIMED

This clinical trial examined whether a strategy of rescue shocks as soon as possible after arrival or a strategy of doing 3 minutes of CPR before rescue shocks improved survival after cardiac arrest.  A separate portion of this trial examined...


ASPIRE

This study examined whether a mechanical device that provided chest compression was superior to usual CPR for persons with cardiac arrest Hallstrom A, Rea TD, Sayre MR, Christenson J, Anton AR, Mosesso VN Jr, Van Ottingham L, Olsufka M, Pennington S...


Vasopressin in Cardiac Arrest

This study compared whether paramedic use of the drug vasopressin addition to standard care would improve survival in persons with cardiac arrest Callaway CW, Hostler D, Doshi AA, Pinchalk M, Roth RN, Lubin J, Newman DH, Kelly LJ. Usefulness of...


Public Access Defibrillation

This study examined whether public placement of automated defibrillators could allow non-medical laypeople to rescue persons with cardiac arrest Hallstrom AP, Ornato JP, Weisfeldt M, Travers A, Christenson J, McBurnie MA, Zalenski R, Becker LB,...