Previous Acute Care Research


Pragmatic Airway Resuscitation Trial (PART)

This research trial studies patients in cardiac arrest.  Cardiac arrest is a medical emergency where the heart stops beating, the patient collapses suddenly, and the patient stops breathing normally. Typically, paramedics are called to the...


Amiodarone, Lidocaine or Placebo (ALPS) - Enrollment Complete

ENROLLMENT IS COMPLETE!  This study has completed enrollment and data analysis is beginning.  Thanks to all members of the community and to the paramedics who conducted this trial!  Results are expected to be known around April 2016...


Prehospital Air Medical Plasma (PAMPer) trial

Although advances in the care of the severely injured patient have occurred over the last decade, the most acute threat to severely injured patients is uncontrolled hemorrhage (bleeding).  This bleeding results in significant early death and...


Progesterone for the Treatment of TBI (PROTECT III) (COMPLETED)

Progesterone for the Treatment of Traumatic Brain Injury (ProTECT™ III) is a research study to see if progesterone, a hormone normally found in our bodies, is useful in limiting the amount of brain damage from traumatic brain injury (TBI).  ...


Hypotensive Resuscitation for Hemorrhagic Shock after Trauma

How Much Intravenous Fluid should be Administered to Trauma Patients? When patients suffer severe trauma (injury), they may have internal or external bleeding.  One consequence of bleeding is that there is less blood available to carry oxygen...


Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma (EPR-CAT)

Trauma patients who suffer a cardiac arrest have a <10% chance of survival, even if their injuries are technically repairable.  Dr. Peter Safar and Colonel Ron Bellamy proposed over 20 years ago that rapid induction of hypothermia could “buy...


Prehospital Lactate (COMPLETED)

This observational study tests whether blood lactate levels in injured patients in an ambulance predicts the need for emergency surgery, blood transfusions or other complications. Lactate will be measured in a drop of blood from patients who...


Continuous Chest Compressions (Enrollment Completed)

This randomized clinical trial will test if one method for performing CPR is better than the other for patients with cardiac arrest.  Cardiac arrest is a condition where the heart stops beating, and which leads to death unless treated...


Hypertonic Saline for Traumatic Brain Injury

This study examined whether patients who were unconscious after a traumatic head injury would have better outcomes when a concentrated salt solution (hypertonic saline) was used by paramedics as the initial intravenous fluid by paramedics.  ...


ROC – Hypertonic Resuscitation

This study examined whether patients with low blood pressure after severe injury would have better outcome when a concentrated salt solution was used by paramedics as the initial intravenous fluid. Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD...