This study examined whether patients with low blood pressure after severe injury would have better outcome when a concentrated salt solution was used by paramedics as the initial intravenous fluid.
Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, Newgard C, Slutsky A, Coimbra R, Emerson S, Minei JP, Bardarson B, Kudenchuk P, Baker A, Christenson J, Idris A, Davis D, Fabian TC, Aufderheide TP, Callaway C, Williams C, Banek J, Vaillancourt C, van Heest R, Sopko G, Hata JS, Hoyt DB; ROC Investigators. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial. JAMA. 2010 Oct 6;304(13):1455-64
Download the press release "NHLBI Stops Enrollment in Study of Concentrated Saline for Patients with Traumatic Brain Injury"
Download the press release "NHLBI Halts Study for Patients with Shock Due to Lack of Survival BenefiLack"